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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in older adults with a body mass index (BMI) of more than 27, provided they also have problems with weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle including a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight reduction for people who are obese or are overweight and also have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical exercise. Results from a medical trial that enrolled patients without diabetes demonstrated that patients had a normal weight loss of four.1% rather than participants have been given placebos) after a 12- month period, while another study involving patients with diabetes type 2 had a typical weight loss of 2% over treatment with placebo at twelve months.

Using two separate drugs to lose weight can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight loss and the people who go through it you should err to the side of caution and let the FDA do its job and demand some research be done so the public knows the side effects and dangers of the medications before we bring them. Keep in mind that drug companies will be in business to generate money and that they would say almost anything to keep people on the medications.

Researchers found out that participants using this drug for any year, dropped excess weight within a month and have kept the body weight off through the entire 56 weeks of the study. Contrave is a combination from the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which can be made up of multiple active ingredient, which can make them far better and safer.

Combo-pilling could be the newest fad or also the newest ahead under scrutiny and therefore it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular may be the fact that at the time of right now there are no long term prescription weightloss pills that have been approved by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug may also raise hypertension and heartrate, and shouldn't be used in those with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure level and pulse rate and must not be used in patients with uncontrolled high blood pressure level, and also by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients on the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.


'The intent with this bill is always to give police force and district attorneys a power tool to address illicit drug use among women that are pregnant through treatment programs," Tennessee governor Bill Haslam said.