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Evidence is increasing that every addiction without exception is related to issues with the brain's reward center, particularly the mesolimbic system. This the main problem regulates reward responses in getting food and sex, plus in nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both after they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it you need to err assisting caution and allow the FDA do its job and demand some research be done so the public understands the side effects and dangers of the medications before we drive them. Keep in mind that drug companies come in business to make money and that they would say anything to keep people on their own medications.

Researchers found out that participants taking this drug to get a year, dropped excess weight within a month and have kept the weight off during the entire 56 weeks with the study. Contrave is a combination with the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs that are made up of several active ingredient, that might make them more efficient and safer.

Combo-pilling could be the newest fad or in addition to this the newest ahead under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills has become popular is the fact that as of right now there aren't long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug may also raise blood pressure levels and pulse rate, and really should not be used in people who have a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must not used in patients with uncontrolled high blood pressure levels, along with by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients which has a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients towards the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.


A pyromaniac, with both psychiatric and medical therapy, can nevertheless be treated. It is best done with behavioral therapy. Psychotherapy treatment alongside behavior modification is the most frequently used treatment. Based on the study of Jon Grant, a mix treatment of drugs and behavioral therapy was found to be successful for pyromania. The utilization of serotonin reuptake inhibitors is also beneficial in governing the impulsive behavior of the patient as with other impulse control disorder. Also of great help for the patient are medications including Lithium, naltrexone, (ReVia), fluoxetine (Prozac), citalopram (Celexa), paroxetene (Paxil), and also other antidepressants.